HTR2C Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13896c
Background:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,elicits a wide array of physiological effects by binding to severalreceptor subtypes, including the 5-HT2 family ofseven-transmembrane-spanning, G-protein-coupled receptors, whichactivate phospholipase C and D signaling pathways. This geneencodes the 2C subtype of serotonin receptor and its mRNA issubject to multiple RNA editing events, where genomically encodedadenosine residues are converted to inosines. RNA editing ispredicted to alter amino acids within the second intracellular loopof the 5-HT2C receptor and generate receptor isoforms that differin their ability to interact with G proteins and the activation ofphospholipase C and D signaling cascades, thus modulatingserotonergic neurotransmission in the central nervous system.Studies in humans have reported abnormalities in patterns of 5-HT2Cediting in depressed suicide victims.
Other Names:
5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C, HTR2C, HTR1C
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13896c was selected from the Center region of HTR2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HTR2C (HGNC:5295)
Gene ID: 3358
Primary Accession: P28335
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,elicits a wide array of physiological effects by binding to severalreceptor subtypes, including the 5-HT2 family ofseven-transmembrane-spanning, G-protein-coupled receptors, whichactivate phospholipase C and D signaling pathways. This geneencodes the 2C subtype of serotonin receptor and its mRNA issubject to multiple RNA editing events, where genomically encodedadenosine residues are converted to inosines. RNA editing ispredicted to alter amino acids within the second intracellular loopof the 5-HT2C receptor and generate receptor isoforms that differin their ability to interact with G proteins and the activation ofphospholipase C and D signaling cascades, thus modulatingserotonergic neurotransmission in the central nervous system.Studies in humans have reported abnormalities in patterns of 5-HT2Cediting in depressed suicide victims.
Other Names:
5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C, HTR2C, HTR1C
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13896c was selected from the Center region of HTR2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: HTR2C (HGNC:5295)
Gene ID: 3358
Primary Accession: P28335
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review