Human Ferritin (H chain) Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1015
Description: Recombinant full length human ferritin (H chain) protein with molecular weight 21.7 kDa.
Background:
Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. It is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. In vertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively; their sequences are about 50% homologous. Ferritin heavy chain (FHC), the primary iron storage factor is an essential mediator of the antioxidant and protective activities of NF-kappaB. FHC is induced downstream of NF-kappaB and is required to prevent sustained JNK activation and, thereby, apoptosis triggered by TNFalpha. FHC-mediated inhibition of JNK signaling depends on suppressing ROS accumulation and is achieved through iron sequestration.The resultssuggest modulation of FHC or, more broadly, of iron metabolism as a potential approach for anti-inflammatory therapy.
Synonyms:
Ferritin heavy chain, Cell proliferation-inducing gene 15 protein, FTH, FTH1, FTHL6
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Tris-HCL(pH8.8±0.2) with 0.05% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. It is a protein of 450 kDa consisting of 24 subunits that is present in every cell type. In vertebrates, these subunits are both the light (L) and the heavy (H) type with an apparent molecular weight of 19 kDA or 21 kDA respectively; their sequences are about 50% homologous. Ferritin heavy chain (FHC), the primary iron storage factor is an essential mediator of the antioxidant and protective activities of NF-kappaB. FHC is induced downstream of NF-kappaB and is required to prevent sustained JNK activation and, thereby, apoptosis triggered by TNFalpha. FHC-mediated inhibition of JNK signaling depends on suppressing ROS accumulation and is achieved through iron sequestration.The resultssuggest modulation of FHC or, more broadly, of iron metabolism as a potential approach for anti-inflammatory therapy.
Synonyms:
Ferritin heavy chain, Cell proliferation-inducing gene 15 protein, FTH, FTH1, FTHL6
Purity: >95% by SDS-PAGE
Storage buffer: Each vial contains 10 mM Tris-HCL(pH8.8±0.2) with 0.05% sodium azide.
Storage and Expiration:
Ship at 4℃. Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
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