Human Trypsinogen II, TG2 Recombinant Protein (Active)
€0.00
In stock
SKU
BRP1092
Description: Recombinant full length human TG2 protein with molecular weight 31 kDa.
Background:
Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It functions as storage of an inactive form of trypsin so that it may be kept in pancreas and released in significant amount when required for protein digestion. Rowen et al. (1996) found thatonly 2 of 3 pancreatically expressed trypsinogen cDNAs correspond to trypsinogen genes in the TCRB locus; T4 was denoted trypsinogen 1 and T8 was denoted trypsinogen 2. The third pancreatic cDNA, identified independently as trypsinogen 3 and 4, is distinct from the third apparently functional trypsinogen gene (T6) in the TCRB locus but related to the other pancreatic trypsinogens. Teich et al. (2004) demonstrated that the E79K mutation in PRSS1 activated anionic trypsinogen 2-fold better than wildtype cationic trypsin did, whereas the common pancreatitis-associated mutants R122H and N29I had no such effect. The observations not only suggested a novel mechanism of action for pancreatitis-associated trypsinogen mutations, but also highlighted the importance of interactions between the 2 major trypsinogen isoforms in the development of genetically determined chronic pancreatitis.
Synonyms:
Trypsinogen II, TG2
Purity: >96% by SDS-PAGE
Storage buffer: Each vial contains Tris-HCl (pH7.4±0.2) with 0.02% NaN3.
Storage and Expiration:
Ship at 4℃.Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
Background:
Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It functions as storage of an inactive form of trypsin so that it may be kept in pancreas and released in significant amount when required for protein digestion. Rowen et al. (1996) found thatonly 2 of 3 pancreatically expressed trypsinogen cDNAs correspond to trypsinogen genes in the TCRB locus; T4 was denoted trypsinogen 1 and T8 was denoted trypsinogen 2. The third pancreatic cDNA, identified independently as trypsinogen 3 and 4, is distinct from the third apparently functional trypsinogen gene (T6) in the TCRB locus but related to the other pancreatic trypsinogens. Teich et al. (2004) demonstrated that the E79K mutation in PRSS1 activated anionic trypsinogen 2-fold better than wildtype cationic trypsin did, whereas the common pancreatitis-associated mutants R122H and N29I had no such effect. The observations not only suggested a novel mechanism of action for pancreatitis-associated trypsinogen mutations, but also highlighted the importance of interactions between the 2 major trypsinogen isoforms in the development of genetically determined chronic pancreatitis.
Synonyms:
Trypsinogen II, TG2
Purity: >96% by SDS-PAGE
Storage buffer: Each vial contains Tris-HCl (pH7.4±0.2) with 0.02% NaN3.
Storage and Expiration:
Ship at 4℃.Upon receipt, aliquot and store at -20℃ or -80℃ for long term. Avoid repeated freeze and thaw cycles.
| Is Featured? | No |
|---|
Write Your Own Review