JMJD4 Blocking Peptide (N-term)
€363.00
In stock
SKU
AC-BP1030a
Background:
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Other Names:
JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4
Target/Specificity:
The synthetic peptide sequence is selected from aa 1-17 of HUMAN JMJD4
Gene Name: JMJD4
Gene ID: 65094
Primary Accession: Q9H9V9
Other Accession: Q32M74
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Other Names:
JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4
Target/Specificity:
The synthetic peptide sequence is selected from aa 1-17 of HUMAN JMJD4
Gene Name: JMJD4
Gene ID: 65094
Primary Accession: Q9H9V9
Other Accession: Q32M74
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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