KDELR2 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14724b
Background:
Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR2 was the second member of the family to beidentified, and it encodes a protein which is 83% identical to theKDELR1 gene product. Alternative splicing results in multipletranscript variants encoding distinct isoforms. [provided byRefSeq].
Other Names:
ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22
Gene Name: KDELR2
Gene ID: 11014
Primary Accession: P33947
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR2 was the second member of the family to beidentified, and it encodes a protein which is 83% identical to theKDELR1 gene product. Alternative splicing results in multipletranscript variants encoding distinct isoforms. [provided byRefSeq].
Other Names:
ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22
Gene Name: KDELR2
Gene ID: 11014
Primary Accession: P33947
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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