KDELR3 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP13180a
Background:
Retention of resident soluble proteins in the lumen ofthe endoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR3 was the third member of the family to beidentified, and it encodes a protein highly homologous to KDELR1and KDELR2 proteins. Two transcript variants of KDELR3 that ariseby alternative splicing, and encode different isoforms of KDELR3receptor, have been described.
Other Names:
ER lumen protein-retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3, KDEL receptor 3, KDELR3
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13180a was selected from the N-term region of KDELR3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: KDELR3
Gene ID: 11015
Primary Accession: O43731
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Retention of resident soluble proteins in the lumen ofthe endoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR3 was the third member of the family to beidentified, and it encodes a protein highly homologous to KDELR1and KDELR2 proteins. Two transcript variants of KDELR3 that ariseby alternative splicing, and encode different isoforms of KDELR3receptor, have been described.
Other Names:
ER lumen protein-retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3, KDEL receptor 3, KDELR3
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13180a was selected from the N-term region of KDELR3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: KDELR3
Gene ID: 11015
Primary Accession: O43731
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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