MAVS Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13783b
Background:
Double-stranded RNA viruses are recognized in a celltype-dependent manner by the transmembrane receptor TLR3 (MIM603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) andRIGI (ROBO3; MIM 608630). These interactions initiate signalingpathways that differ in their initial steps but converge in theactivation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB(IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1(MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM603734). Activated IRF3 and NFKB induce transcription of IFNB(IFNB1; MIM 147640). For the TLR3 pathway, the intermediarymolecule before the pathways converge is the cytoplasmic proteinTRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein ismitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed16239922]).
Other Names:
Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, VISA, MAVS, IPS1, KIAA1271, VISA
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13783b was selected from the C-term region of MAVS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MAVS {ECO:0000303|PubMed:16125763, ECO:0000312|HGNC:HGNC:29233}
Gene ID: 57506
Primary Accession: Q7Z434
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Double-stranded RNA viruses are recognized in a celltype-dependent manner by the transmembrane receptor TLR3 (MIM603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) andRIGI (ROBO3; MIM 608630). These interactions initiate signalingpathways that differ in their initial steps but converge in theactivation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB(IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1(MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM603734). Activated IRF3 and NFKB induce transcription of IFNB(IFNB1; MIM 147640). For the TLR3 pathway, the intermediarymolecule before the pathways converge is the cytoplasmic proteinTRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein ismitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed16239922]).
Other Names:
Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, VISA, MAVS, IPS1, KIAA1271, VISA
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13783b was selected from the C-term region of MAVS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MAVS {ECO:0000303|PubMed:16125763, ECO:0000312|HGNC:HGNC:29233}
Gene ID: 57506
Primary Accession: Q7Z434
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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