Phospho-ATXN1(S776) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3592a
Background:
The function of the ataxins is not known. The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders.
Other Names:
Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3592a was selected from the region of human Phospho-ATXN1-pS776. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ATXN1
Gene ID: 6310
Primary Accession: P54253
Other Accession: NP_000323
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The function of the ataxins is not known. The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders.
Other Names:
Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3592a was selected from the region of human Phospho-ATXN1-pS776. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ATXN1
Gene ID: 6310
Primary Accession: P54253
Other Accession: NP_000323
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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