Phospho-TSC1(S505) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3470a
Background:
TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Other Names:
Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3470a was selected from the region of human Phospho-TSC1-S505. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TSC1 {ECO:0000303|PubMed:9242607, ECO:0000312|HGNC:HGNC:12362}
Gene ID: 7248
Primary Accession: Q92574
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Other Names:
Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3470a was selected from the region of human Phospho-TSC1-S505. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TSC1 {ECO:0000303|PubMed:9242607, ECO:0000312|HGNC:HGNC:12362}
Gene ID: 7248
Primary Accession: Q92574
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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