PLOD2 polyclonal, anti-human, rat
€388.00
In stock
SKU
BS8602
Background:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alternative Name:
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, Lysyl hydroxylase 2, LH2, PLOD2
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: PLOD2 polyclonal antibody detects endogenous levels of PLOD2 protein.
Immunogen:
Recombinant full length Human PLOD2.
MW: ~ 85kDa
Swis Prot.: O00469
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alternative Name:
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, Lysyl hydroxylase 2, LH2, PLOD2
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: PLOD2 polyclonal antibody detects endogenous levels of PLOD2 protein.
Immunogen:
Recombinant full length Human PLOD2.
MW: ~ 85kDa
Swis Prot.: O00469
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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