SCNM1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1446a
Background:
SCNM1 is a zinc finger protein and putative splicing factor that modifies phenotypic expression of Scn8a mutations in mouse models. Phylogenetic comparison of zinc finger sequences placed SCNM1 within the U1C subfamily of RNA binding proteins that are commonly found in RNA-processing proteins. The SCNM1 protein is localized exclusively to the nucleus. Mutations in the mouse Scn8a gene cause inherited movement disorders that range in severity from tremor to ataxia, dystonia, and juvenile lethality. The severity of the hypomorphic allele Scn8a(medJ) is determined by the unlinked modifier gene Scnm1. The modifier mutation, R187X, is characteristic of strain C57BL/6J and reduces the abundance of correctly spliced sodium channel transcripts below the threshold for survival. Mice with the Scn8a(medJ) mutation on any strain except C57BL/6J have 10% of Scn8a transcript correctly spliced and develop a progressive disorder with dystonia and ataxia but live longer than 1.5 years. The same mutation on a C57BL/6J background results in only 5% of correctly spliced transcript, leading to paralysis and survival less than one month.
Other Names:
Sodium channel modifier 1, SCNM1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1446a was selected from the N-term region of human SCNM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SCNM1
Gene ID: 100534012;79005
Primary Accession: Q9BWG6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
SCNM1 is a zinc finger protein and putative splicing factor that modifies phenotypic expression of Scn8a mutations in mouse models. Phylogenetic comparison of zinc finger sequences placed SCNM1 within the U1C subfamily of RNA binding proteins that are commonly found in RNA-processing proteins. The SCNM1 protein is localized exclusively to the nucleus. Mutations in the mouse Scn8a gene cause inherited movement disorders that range in severity from tremor to ataxia, dystonia, and juvenile lethality. The severity of the hypomorphic allele Scn8a(medJ) is determined by the unlinked modifier gene Scnm1. The modifier mutation, R187X, is characteristic of strain C57BL/6J and reduces the abundance of correctly spliced sodium channel transcripts below the threshold for survival. Mice with the Scn8a(medJ) mutation on any strain except C57BL/6J have 10% of Scn8a transcript correctly spliced and develop a progressive disorder with dystonia and ataxia but live longer than 1.5 years. The same mutation on a C57BL/6J background results in only 5% of correctly spliced transcript, leading to paralysis and survival less than one month.
Other Names:
Sodium channel modifier 1, SCNM1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1446a was selected from the N-term region of human SCNM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SCNM1
Gene ID: 100534012;79005
Primary Accession: Q9BWG6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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