Human IL-13 R alpha 2 Elisa Kit

Background:
Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Long Name: Interleukin 13 Receptor alpha 2

Synonyms:
CD213a2, CT19, IL-13 R alpha 2, IL13BP, IL13R alpha 2, IL-13R subunit alpha-2, IL13R, IL-13R, IL13RA2, IL-13Ra2, IL-13R-alpha-2,

Sample Type:
Serum, Plasma, Cell culture supernatant.

Assay Lenght: 3.5h