SLC46A1 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP14994c
Background:
This gene encodes a transmembrane proton-coupled folatetransporter protein that facilitates the movement of folate andantifolate substrates across cell membranes optimally in acidic pHenvironments. This protein is also expressed in the brain andchoroid plexus where it transports folates into the central nervoussystem. This protein further functions as a transmembrane hemetransporter in duodenal enterocytes and, potentially, in othertissues like liver and kidney. Its localization to the apicalmembrane or cytoplasm of intestinal cells is modulated by dietaryiron levels. Mutations in this gene cause the autosomal recessivehereditary folate malabsorption (HFM) disease. HFM is characterizedby folate deficiency due to reduced intestinal folate absorptionand subsequent anemia, hypoimmunoglobulinemia, and recurrentinfections.
Other Names:
Proton-coupled folate transporter, G21, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1, SLC46A1, HCP1, PCFT
Gene Name: SLC46A1 {ECO:0000303|PubMed:20686069, ECO:0000312|HGNC:HGNC:30521}
Gene ID: 113235
Primary Accession: Q96NT5
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a transmembrane proton-coupled folatetransporter protein that facilitates the movement of folate andantifolate substrates across cell membranes optimally in acidic pHenvironments. This protein is also expressed in the brain andchoroid plexus where it transports folates into the central nervoussystem. This protein further functions as a transmembrane hemetransporter in duodenal enterocytes and, potentially, in othertissues like liver and kidney. Its localization to the apicalmembrane or cytoplasm of intestinal cells is modulated by dietaryiron levels. Mutations in this gene cause the autosomal recessivehereditary folate malabsorption (HFM) disease. HFM is characterizedby folate deficiency due to reduced intestinal folate absorptionand subsequent anemia, hypoimmunoglobulinemia, and recurrentinfections.
Other Names:
Proton-coupled folate transporter, G21, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1, SLC46A1, HCP1, PCFT
Gene Name: SLC46A1 {ECO:0000303|PubMed:20686069, ECO:0000312|HGNC:HGNC:30521}
Gene ID: 113235
Primary Accession: Q96NT5
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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