TMOD4 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8427
Background:
Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments . A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments . Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans. TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively. TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 . The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein . The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B.
Alternative Name:
Tropomodulin-4, Skeletal muscle tropomodulin, Sk-Tmod, TMOD4
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: TMOD4 polyclonal antibody detects endogenous levels of TMOD4 protein.
Immunogen:
Recombinant full length Human TMOD4.
MW: ~ 39 kDa
Swis Prot.: Q9NZQ9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments . A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments . Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans. TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively. TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 . The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein . The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B.
Alternative Name:
Tropomodulin-4, Skeletal muscle tropomodulin, Sk-Tmod, TMOD4
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: TMOD4 polyclonal antibody detects endogenous levels of TMOD4 protein.
Immunogen:
Recombinant full length Human TMOD4.
MW: ~ 39 kDa
Swis Prot.: Q9NZQ9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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