TP63 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13965b
Background:
This gene encodes a member of the p53 family oftranscription factors. An animal model, p63 -/- mice, has beenuseful in defining the role this protein plays in the developmentand maintenance of stratified epithelial tissues. p63 -/- mice haveseveral developmental defects which include the lack of limbs andother tissues, such as teeth and mammary glands, which develop as aresult of interactions between mesenchyme and epithelium. Mutationsin this gene are associated with ectodermal dysplasia, and cleftlip/palate syndrome 3 (EEC3); split-hand/foot malformation 4(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULTsyndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammarysyndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Bothalternative splicing and the use of alternative promoters resultsin multiple transcript variants encoding different proteins. Manytranscripts encoding different proteins have been reported but thebiological validity and the full-length nature of these variantshave not been determined.
Other Names:
Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13965b was selected from the C-term region of TP63. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TP63
Gene ID: 8626
Primary Accession: Q9H3D4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the p53 family oftranscription factors. An animal model, p63 -/- mice, has beenuseful in defining the role this protein plays in the developmentand maintenance of stratified epithelial tissues. p63 -/- mice haveseveral developmental defects which include the lack of limbs andother tissues, such as teeth and mammary glands, which develop as aresult of interactions between mesenchyme and epithelium. Mutationsin this gene are associated with ectodermal dysplasia, and cleftlip/palate syndrome 3 (EEC3); split-hand/foot malformation 4(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULTsyndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammarysyndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Bothalternative splicing and the use of alternative promoters resultsin multiple transcript variants encoding different proteins. Manytranscripts encoding different proteins have been reported but thebiological validity and the full-length nature of these variantshave not been determined.
Other Names:
Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13965b was selected from the C-term region of TP63. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TP63
Gene ID: 8626
Primary Accession: Q9H3D4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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