AKAP13 antibody (clone 3D6), anti-human
€435.00
In stock
SKU
AC-AT1085a
Catalog Number: AC-AT1085a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, E
Request Information AC-AT1085a">Request Information
Background:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.
Other Names:
A-kinase anchor protein 13, AKAP-13, AKAP-Lbc, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, Human thyroid-anchoring protein 31, Lymphoid blast crisis oncogene, LBC oncogene, Non-oncogenic Rho GTPase-specific GTP exchange factor, Protein kinase A-anchoring protein 13, PRKA13, p47, AKAP13, BRX, HT31, LBC
Antigen Type:
Recombinant Protein
Gene Name: AKAP13
Gene ID: 11214
NCBI Accession: NP_001257475.1;NP_006729.4;NP_009131.2
Primary Accession: Q12802
Other Accession: NM_006738
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.
Other Names:
A-kinase anchor protein 13, AKAP-13, AKAP-Lbc, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, Human thyroid-anchoring protein 31, Lymphoid blast crisis oncogene, LBC oncogene, Non-oncogenic Rho GTPase-specific GTP exchange factor, Protein kinase A-anchoring protein 13, PRKA13, p47, AKAP13, BRX, HT31, LBC
Antigen Type:
Recombinant Protein
Gene Name: AKAP13
Gene ID: 11214
NCBI Accession: NP_001257475.1;NP_006729.4;NP_009131.2
Primary Accession: Q12802
Other Accession: NM_006738
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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