AKT1 antibody (clone 6F11), anti-human, mouse, rat
€435.00
In stock
SKU
AC-AT1099a
Catalog Number: AC-AT1099a
Size: 100 µg
Isotype: mouse IgG2a Lambda
Applications: WB, IF
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Size: 100 µg
Isotype: mouse IgG2a Lambda
Applications: WB, IF
Request Information AC-AT1099a">Request Information
Background:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
Other Names:
RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC
Antigen Type:
Recombinant Protein
Gene Name: AKT1
Gene ID: 207
NCBI Accession: NP_001014431.1;NP_001014432.1;NP_005154.2
Primary Accession: P31749
Other Accession: BC000479
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
Other Names:
RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC
Antigen Type:
Recombinant Protein
Gene Name: AKT1
Gene ID: 207
NCBI Accession: NP_001014431.1;NP_001014432.1;NP_005154.2
Primary Accession: P31749
Other Accession: BC000479
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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