CLDN14 Blocking Peptide (C-term)
€363.00
In stock
SKU
AC-BP20035b
Background:
Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. The protein encoded by this gene, amember of the claudin family, is an integral membrane protein and acomponent of tight junction strands. The encoded protein also bindsspecifically to the WW domain of Yes-associated protein. Defects inthis gene are the cause of an autosomal recessive form ofnonsyndromic sensorineural deafness. It is also reported that foursynonymous variants in this gene are associated with kidney stonesand reduced bone mineral density. Several transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
Other Names:
Claudin-14, CLDN14
Target/Specificity:
The synthetic peptide sequence is selected from aa 187-200 of HUMAN CLDN14
Gene Name: CLDN14
Gene ID: 23562
Primary Accession: O95500
Other Accession: NP_036262.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. The protein encoded by this gene, amember of the claudin family, is an integral membrane protein and acomponent of tight junction strands. The encoded protein also bindsspecifically to the WW domain of Yes-associated protein. Defects inthis gene are the cause of an autosomal recessive form ofnonsyndromic sensorineural deafness. It is also reported that foursynonymous variants in this gene are associated with kidney stonesand reduced bone mineral density. Several transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
Other Names:
Claudin-14, CLDN14
Target/Specificity:
The synthetic peptide sequence is selected from aa 187-200 of HUMAN CLDN14
Gene Name: CLDN14
Gene ID: 23562
Primary Accession: O95500
Other Accession: NP_036262.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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