CYP27A1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2853a
Background:
CYP27A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in CYP27A1 gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.
Other Names:
Sterol 26-hydroxylase, mitochondrial, 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase, Cytochrome P-450C27/25, Cytochrome P450 27, Sterol 27-hydroxylase, Vitamin D(3) 25-hydroxylase, CYP27A1, CYP27
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2853a was selected from the N-term region of human CYP27A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CYP27A1 {ECO:0000303|PubMed:21411718, ECO:0000312|HGNC:HGNC:2605}
Gene ID: 1593
Primary Accession: Q02318
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CYP27A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in CYP27A1 gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.
Other Names:
Sterol 26-hydroxylase, mitochondrial, 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase, Cytochrome P-450C27/25, Cytochrome P450 27, Sterol 27-hydroxylase, Vitamin D(3) 25-hydroxylase, CYP27A1, CYP27
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2853a was selected from the N-term region of human CYP27A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CYP27A1 {ECO:0000303|PubMed:21411718, ECO:0000312|HGNC:HGNC:2605}
Gene ID: 1593
Primary Accession: Q02318
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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